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Early Diagnosis of MS

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Challenge Description

Background

MS is widely recognized as the most common neurological and inflammatory disorder of the central nervous system (CNS) in the adult population (Rostasy, 2007). It is a chronic, recurrent, progressive autoimmune disorder characterized by repeated episodes of inflammation of the white matter nervous tissue of the CNS. The location of the inflammation varies from person to person and from episode to episode, and as such results in a variety of clinical symptoms.

The diagnosis of MS is largely based upon evidence of lesions in the CNS caused by inflammatory demyelination (Gelfand, 2014). In most instances, diagnosis of MS requires a full clinical history and neurological examination, along with brain and spine imaging.

 

Finding biomarkers for MS, to help early detection, disease-modifying treatments, diagnosis, selection of therapies, treatment tailoring, and prediction of the disease course, seems quite complex and remains a major unmet need.

 

This challenge focus is to find non-invasive diagnosis methods that could have been originally developed for diagnosis of other medical condition and can be adjusted to MS diagnosis. As an example, Optical Coherence Tomography (OCT) has been increasingly used as a research tool to detect damage that occurs to the nerves in the back of the eye. It is carried out painlessly, with a small and inexpensive machine that can fit into an examining room. Growing evidence has suggested that OCT findings can mirror MS-inflicted damage that occurs in the brain.

 

The challenge

Find non-invasive diagnosis solution/method that can be implemented for MS diagnosis. The method can be based on any technology and should be supported by reputable scientific literature. Clinical supportive data could be a major advantage.  

Deliverables

Describe your method & solution. Enclose sketches, drawings, charts, videos, graphs, studies or any other visuals to demonstrate your solution

The description of the solution should include:

  • The technology, mode of operation
  • The supporting literature  and  clinical data
  • The maturity level of the solution and potential time to market
  • Costs/ prices (can be an estimated range)
  • Information about the company (+ website) & team

Key emphases

Better ranking will be given to mature methods, clinical supportive info, ease of use and affordable cost of test

 

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